Биоресурсная коллекция мышей с направленно измененным геномом МГУ
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Линии мышей с направленно измененным геномом

Название
Тип ред. гена ⓘ KI: Knock-in — введение в геном новой последовательности — например, метки, репортера или мутантного варианта гена.

KO: Knockout — полное или частичное выключение гена, приводящее к утрате его функции. Используется для изучения последствий отсутствия гена.

SNV: SNV (single-nucleotide variant) — изменение одного нуклеотида в последовательности ДНК, моделирующее естественные мутации.

SNV/SNV: SNV/SNV (single-nucleotide variant) — наличие двух различных точечных замен — в разных аллелях или участках гена.
Ген
Синонимы
Продукт гена
Gene ID
MGI ID
Ensembl ID
OMIM ID
B6-Chek2d13
KO
Chek2 (Mus musculus)
CHK2; Cds1; Rad53; HUCDS1
CHEK2 (checkpoint kinase 2)
50883
MGI:1355321
ENSMUSG00000029521
604373
B6-Chek2d2
KO
Chek2 (Mus musculus)
CHK2; Cds1; Rad53; HUCDS1
CHEK2 (checkpoint kinase 2)
50883
MGI:1355321
ENSMUSG00000029521
604373
B6-Chek2i1
KO
Chek2 (Mus musculus)
CHK2; Cds1; Rad53; HUCDS1
CHEK2 (checkpoint kinase 2)
50883
MGI:1355321
ENSMUSG00000029521
604373
B6-Eif4e1bd13i4
KO
Eif4e1b (Mus musculus)
Gm273; Eif4eloo
EIF4E1B (Eukaryotic Translation Initiation Factor 4E Family Member 1B)
218268
MGI:2685119
ENSMUSG00000074895
133440
B6-Eif4e1bd19
KO
Eif4e1b (Mus musculus)
Gm273; Eif4eloo
EIF4E1B (Eukaryotic Translation Initiation Factor 4E Family Member 1B)
218268
MGI:2685119
ENSMUSG00000074895
133440
B6-Lepd10
KO
Lep (Mus musculus)
ob; obese
leptin
16846
MGI:104663
ENSMUSG00000059201
164160
B6-Leprd10
KO
Lepr (Mus musculus)
db; Obr; obl; B219; LEP-R; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like
leptin receptor
16847
MGI:104993
ENSMUSG00000057722
601007
B6-Mettl4d4
KO
Mettl4 (Mus musculus)
HsT661; 2410198H06Rik; A730091E08Rik
methyltransferase 4, N6-adenosine
76781
MGI:1924031
ENSMUSG00000055660
619626
B6-Mettl4d8
KO
Mettl4 (Mus musculus)
HsT661; 2410198H06Rik; A730091E08Rik
methyltransferase 4, N6-adenosine
76781
MGI:1924031
ENSMUSG00000055660
619626
B6-mTercC23A
SNV
Terc (Mus musculus)
mTR; mTER
telomerase RNA component
21748
MGI:109558
ENSMUSG00000118406
602322
B6-mTercd7
KO
Terc (Mus musculus)
mTR; mTER
telomerase RNA component
21748
MGI:109558
ENSMUSG00000118406
602322
B6-Nrf2DNeh2
VAR
Nfe2l2 (Mus musculus)
Nrf2
NFE2 like bZIP transcription factor 2
18024
MGI:108420
ENSMUSG00000015839
600492
B6-Thumpd2i1
KO
Thumpd2 (Mus musculus)
2810025A12Rik
THUMP domain containing 2
72167
MGI:1919417
ENSMUSG00000024246
611751
B6;CBA-1700008O03Rikd2796
KO
1700008O03Rik (Mus musculus)
C19orf81 (Homo sapiens)
putative uncharacterized protein Chromosome 19 open reading frame 81
69349
MGI:1916599
ENSMUSG00000008028
-
B6;CBA-1700008O03Rikd2804
KO
1700008O03Rik (Mus musculus)
C19orf81 (Homo sapiens)
putative uncharacterized protein Chromosome 19 open reading frame 81
69349
MGI:1916599
ENSMUSG00000008028
-
B6;CBA-ecDamKI
KI
ecDam (Escherichia coli)
ECK3374
DNA adenine methyltransferase
947893
-
-
-
B6;CBA-Flad1A418V/R542X
SNV/SNV
Flad1 (Mus musculus)
Pp591; A930017E24Rik
flavin adenine dinucleotide synthetase 1
319945
MGI:2443030
ENSMUSG00000042642
610595
B6;CBA-Flad1A418V
SNV
Flad1 (Mus musculus)
Pp591; A930017E24Rik
flavin adenine dinucleotide synthetase 1
319945
MGI:2443030
ENSMUSG00000042642
610595
B6;CBA-Flad1d1
KO
Flad1 (Mus musculus)
Pp591; A930017E24Rik
flavin adenine dinucleotide synthetase 1
319945
MGI:2443030
ENSMUSG00000042642
610595
B6;CBA-Flad1d10
KO
Flad1 (Mus musculus)
Pp591; A930017E24Rik
flavin adenine dinucleotide synthetase 1
319945
MGI:2443030
ENSMUSG00000042642
610595
B6;CBA-Flad1d2
KO
Flad1 (Mus musculus)
Pp591; A930017E24Rik
flavin adenine dinucleotide synthetase 1
319945
MGI:2443030
ENSMUSG00000042642
610595
B6;CBA-Flad1i1
KO
Flad1 (Mus musculus)
Pp591; A930017E24Rik
flavin adenine dinucleotide synthetase 1
319945
MGI:2443030
ENSMUSG00000042642
610595
B6;CBA-Flad1R542X
SNV
Flad1 (Mus musculus)
Pp591; A930017E24Rik
flavin adenine dinucleotide synthetase 1
319945
MGI:2443030
ENSMUSG00000042642
610595
B6;CBA-Gprc5ad19
KO
Gprc5a (Mus musculus)
Rai3; Raig1
G protein-coupled receptor, family C, group 5, member A
232431
MGI:1891250
ENSMUSG00000046733
604138
B6;CBA-Gprc5ai1
KO
Gprc5a (Mus musculus)
Rai3; Raig1
G protein-coupled receptor, family C, group 5, member A
232431
MGI:1891250
ENSMUSG00000046733
604138
B6;CBA-HA-Mkrn3
KI
Mkrn3 (Mus musculus)
Zfp127; D7H15S9-1
Makorin ring finger protein 3
22652
MGI:2181178
ENSMUSG00000070527
603856
B6;CBA-HA-NSUN7
KI
Nsun7 (Mus musculus)
4921525L17Rik
NOP2/Sun RNA methyltransferase family member 7
70918
MGI:1918168
ENSMUSG00000029206
617185
B6;CBA-HA-NSUN7C382A
VAR
Nsun7 (Mus musculus)
4921525L17Rik
NOP2/Sun RNA methyltransferase family member 7
70918
MGI:1918168
ENSMUSG00000029206
617185
B6;CBA-HGSNATd1
KO
Hgsnat (Mus musculus)
Tmem76; D8Ertd354e; 9430010M12Rik
Heparan-alpha-glucosaminide N-acetyltransferase
52120
MGI:1196297
ENSMUSG00000037260
610453
B6;CBA-HGSNATd8
KO
Hgsnat (Mus musculus)
Tmem76; D8Ertd354e; 9430010M12Rik
Heparan-alpha-glucosaminide N-acetyltransferase
52120
MGI:1196297
ENSMUSG00000037260
610453
B6;CBA-IL1RL1d7
KO
IL1RL1 (Mus musculus)
T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1
Interleukin 1 receptor like 1
17082
MGI:98427
ENSMUSG00000026069
601203
B6;CBA-IL33d13
KO
IL33 (Mus musculus)
Il-33; Il1f11; NF-HEV; 9230117N10Rik
interleukin 33
77125
MGI:1924375
ENSMUSG00000024810
608678
B6;CBA-IL33d4
KO
IL33 (Mus musculus)
Il-33; Il1f11; NF-HEV; 9230117N10Rik
interleukin 33
77125
MGI:1924375
ENSMUSG00000024810
608678
B6;CBA-Mettl15d2
KO
Mettl15 (Mus musculus)
Mett5d1; 0610027B03Rik
methyltransferase like 15
76894
MGI:1924144
ENSMUSG00000057234
618711
B6;CBA-Mettl15d2i4
KO
Mettl15 (Mus musculus)
Mett5d1; 0610027B03Rik
methyltransferase like 15
76894
MGI:1924144
ENSMUSG00000057234
618711
B6;CBA-Mettl15i1
KO
Mettl15 (Mus musculus)
Mett5d1; 0610027B03Rik
methyltransferase like 15
76894
MGI:1924144
ENSMUSG00000057234
618711
B6;CBA-Mkrn3d1
KO
Mkrn3 (Mus musculus)
Zfp127; D7H15S9-1
Makorin ring finger protein 3
22652
MGI:2181178
ENSMUSG00000070527
603856
B6;CBA-Mkrn3d4
KO
Mkrn3 (Mus musculus)
Zfp127; D7H15S9-1
Makorin ring finger protein 3
22652
MGI:2181178
ENSMUSG00000070527
603856
B6;CBA-Mkrn3d7
KO
Mkrn3 (Mus musculus)
Zfp127; D7H15S9-1
Makorin ring finger protein 3
22652
MGI:2181178
ENSMUSG00000070527
603856
B6;CBA-Mkrn3i3d7
VAR
Mkrn3 (Mus musculus)
Zfp127; D7H15S9-1
Makorin ring finger protein 3
22652
MGI:2181178
ENSMUSG00000070527
603856
B6;CBA-Mtlnd8
KO
1500011k16Rik (Mus musculus)
Mtln; Mpm; Moxi; 1500011K16Rik
mitoregulin
67885
MGI:1915135
ENSMUSG00000051319
620770
B6;CBA-Mtlnd82
KO
1500011k16Rik (Mus musculus)
Mtln; Mpm; Moxi; 1500011K16Rik
mitoregulin
67885
MGI:1915135
ENSMUSG00000051319
620770
B6;CBA-Mtrfri1
KO
Mtrfr (Mus musculus)
2810006K23Rik
MTRFR (Mitochondrial Translation Release Factor)
72650
MGI:1919900
ENSMUSG00000047635
613541
B6;CBA-NSUN7C382A
SNV
Nsun7 (Mus musculus)
4921525L17Rik
NOP2/Sun RNA methyltransferase family member 7
70918
MGI:1918168
ENSMUSG00000029206
617185
B6;CBA-NSUN7d38
KO
Nsun7 (Mus musculus)
4921525L17Rik
NOP2/Sun RNA methyltransferase family member 7
70918
MGI:1918168
ENSMUSG00000029206
617185
B6;CBA-NSUN7i2
KO
Nsun7 (Mus musculus)
4921525L17Rik
NOP2/Sun RNA methyltransferase family member 7
70918
MGI:1918168
ENSMUSG00000029206
617185
B6;CBA-Park2i1
KO
Park2
PRKN, Park2, Parkin
Parkin RBR E3 ubiquitin protein ligase
50873
MGI:1355296
ENSMUSG00000023826
602544
B6;CBA-Plaud10
KO
Plau (Mus musculus)
uPA; u-PA
Plasminogen activator, urokinase
18792
MGI:97611
ENSMUSG00000021822
191840
B6;CBA-Plaurs1243306395
MNV
Plau (Mus musculus)
uPA; u-PA
Plasminogen activator, urokinase
18792
MGI:97611
ENSMUSG00000021822
191840
B6;CBA-Plxna3rs139336954
MNV
Plxna3 (Mus musculus)
SEX; Plxa3; Plxn3; Plxn4; PlexA3; mKIAA4078
Plexin A3
18846
MGI:107683
ENSMUSG00000031398
300022
B6;CBA-SLC5a6iA
KO
Slc5a6 (Mus musculus)
E430023I20
solute carrier family 5 (sodium-dependent vitamin transporter), member 6 (SMVT)
330064
MGI:2660847
ENSMUSG00000006641
604024
B6;CBA-SLC5a6P437Q
SNV
Slc5a6 (Mus musculus)
E430023I20
solute carrier family 5 (sodium-dependent vitamin transporter), member 6 (SMVT)
330064
MGI:2660847
ENSMUSG00000006641
604024
B6;CBA-SLC5a6R280W/P437Q
MNV/SNV
Slc5a6 (Mus musculus)
E430023I20
solute carrier family 5 (sodium-dependent vitamin transporter), member 6 (SMVT)
330064
MGI:2660847
ENSMUSG00000006641
604024
B6;CBA-SLC5a6R280W
MNV
Slc5a6 (Mus musculus)
E430023I20
solute carrier family 5 (sodium-dependent vitamin transporter), member 6 (SMVT)
330064
MGI:2660847
ENSMUSG00000006641
604024
B6;CBA-Spout1d1
KO
Spout1 (Mus musculus)
CENP-32; D2Wsu81e; 9930028P05
SPOUT domain containing methyltransferase 1
227695
MGI:106544
ENSMUSG00000039660
617614
B6;CBA-Spout1d14
KO
Spout1 (Mus musculus)
CENP-32; D2Wsu81e; 9930028P05
SPOUT domain containing methyltransferase 1
227695
MGI:106544
ENSMUSG00000039660
617614
B6;CBA-XRCCd26
KO
Xrcc2 (Mus musculus)
RecA; RAD51; 4921524O04Rik; 8030409M04Rik
X-ray repair cross complementing 2
57434
MGI:1927345
ENSMUSG00000028933
600375
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